In vitro bioactivity and antibacterial capacity of 45S5 Bioglass®-based compositions containing alumina and strontium

A modified 45S5 Bioglass® containing 2 mol% alumina and strontium oxide was prepared. In vitro bioactivity in powder monolithic samples conducted. Fourier transform infrared analysis pH change simulated body fluid were investigated for after 480 min of immersion. Additionally, X-ray diffraction scanning electron microscopy 7 14 days immersion samples. The formation phosphate carbonate phase precursors hydroxycarbonate apatite observed samples, the pattern morphology confirmed It seems that changes composition did not affect reactivity but caused a decrease maxima pH. Cytotoxicity cell viability obtained by using NCTC clone 929 line show any significant loss or cytotoxicity. Moreover, overnight incubation, demonstrated safe disinfection Escherichia coli. For these reasons, use new bioactive glasses can be considered promising alternative reconstruction bone defects even treatment suppression infections.